NUCLEOCEL®

Enantioselective Separation of Chiral Compounds

Nucleocel has a chiral selector that is based on modified cellulose (Nucleocel Delta) or amylose (Nucleocel Alpha) derivative which is coated on an unparalleled quality silica support.

Both (Alpha and Delta) HPLC sorbents provide excellent enantioselective properties for a large number of known chiral molecules, which can be separated with high a-values.

  • Base material silica, chiral selector amylose tris-(3, 5-dimethylphenylcarbamate) USP L51
  • High-resolution type (S) with 5 µm particle size
  • Allows use of shorter columns (150 mm) for faster separations
  • Pressure stability up to ~150 bar (2000 psi)

Nucleocel Alpha – enantiomer separation based on an amylose derivative

Nucleocel Alpha for normal phase applications:

  • Eluent in column n-heptane-propanol-2 (90:10, v/v)
  • Typical eluents are heptane-propanol mixtures

Nucleocel Alpha-RP for reversed-phase applications:

  • Eluent in column acetonitrile-water (50:50, v/v)
  • Designed for use either in polar organic mode or with eluents containing high concentrations of chaotropic salts such as perchlorate
nucleocel

Similar Phases:

  • Chiralpak® AD
  • Kromasil® AmyCoat™
  • Europak 01

Recommended Applications:

  • Pharmaceutically active compounds
  • Chiral pollutants (e. g. herbicides, PCB)
  • Chiral compounds in food (dyes, preservatives)
  • Chiral catalysts and bioorganic compounds