Automated flash chromatography is a type of chromatography that uses a flash chromatography system that is automated and controlled by a computer. In this method, a sample is applied to the top of a column filled with a stationary phase, which is usually a solid adsorbent material. The sample is then separated into its component parts as it is passed through the column by the flow of a mobile phase, which is typically a liquid solvent or mixture of solvents.
Automated flash chromatography systems are designed to improve the efficiency and reproducibility of the separation process. They typically have a pump to control the flow of the mobile phase, a detector to monitor the progress of the separation, and a computer to control the system and analyze the results. Some systems also have automatic sample loading and unloading capabilities, as well as the ability to switch between different columns and mobile phases.
Automated flash chromatography is widely used in the chemical and pharmaceutical industries for the purification and separation of compounds, as well as in research and development. It is particularly useful for the purification of small- to medium-sized samples, as it allows for rapid separation with high resolution and recovery.